A 2009 study conducted on matricaria recutita (chamomile) extract was observed to provide modest anti-anxiety benefits in patients with mild to moderate GAD (Generalized Anxiety Disorder). The study was double-blind and placebo-controlled, and included 61 healthy participants. During the course of the study, one participant in each of the placebo and treatment groups dropped out due to an adverse event. Researchers concluded that further studies are needed to replicate the findings.
J Clin Psychopharmacol. 2009 Aug; 29(4): 378-82.