Mangosteen and Immune Function
A recent clinical study of a mangosteen dietary supplement with vitamins and minerals was found to show positive benefits to human immune function. A randomized double blind placebo-controlled trial was conducted with 59 healthy human volunteers over the course of 30 days. At the conclusion of the trial, the data indicated a statistically significant change in immune function markers from the baseline in the study group versus the placebo group. The changes were positive and pointed to enhance immune function. Subjects from the study group also self reported a greater sense of improved health. Further studies evaluating the effects of the mangosteen product on different population groups with emphasis on long term outcomes is warranted. Click here for more information
A Geranylated Biphenyl Derivative From Garcinia Mangostana
Garcinia mangostana L. (Clusiaceae) is a tree found in Sri Lanka and other South East Asian countries, which is very popular due to its delicious fruits. Medicinal uses such as for the treatment of diarrhea, dysentery, skin infections and as an anti-inflammatory agent are reported. Extensive chemical investigations have been conducted on the fruit hull and the leaves of G. mangostana. So far, over forty natural products belonging to xanthones, terpenoids and sugars are reported from this species with a variety of biological activities. Read More.
Xanthones Induce Cell-Cycle Arrest and Apoptosis in Human Colon Cancer DLD-1 Cells
Mangosteen, Garcinia mangostana L. is a tree found in South East Asia, and its pericarp have been used as traditional medicine for treatment of skin infection wounds for many years. Phytochemical studies have shown that they contain a variety of secondary metabolites such as oxygenated and prenylated xanthones. Recent studies have revealed that these xanthones exhibited a variety of biological activities containing anti-inflammatory, antibacterial, and anti cancer effects. Read More.
A Geranylated Biphenyl Derivative from Garcinia Mangostana
Garcinia mangostana L. (Clusiaceae) is a tree found in Sri Lanka and other South East Asian countries, which is very popular due to its delicious fruits. Medicinal uses such as for the treatment of diarrhea, dysentery, skin infections and as an anti-inflammatory agent are reported . Extensive chemical investigations have been conducted on the fruit hull and leaves of G. mangostana. So far, over forty natural products belonging to xanthones, terpenoids and sugars are reported from this species [1-8] with a variety of biological activities [1,9-13]. Read More.
Antibacterial Activity of Xanthones from Guttiferaeous Plants Against Methicillin-Resistant Staphylococcus Aureus
Extracts of Garcinia mangostana (Guttiferae) showing inhibitory effects against the growth of S. aureus NIHJ 209p were fractionated according to guidance obtained from bioassay and some of the components with activity against methicillin-resistant, Staphylococcus aureus (MRSA) were characterized. Read More.
Induction of Apoptosis by Xanthones from Mangosteen Human Leukemia Cell Lines
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, a-mangostin showed complete inhibition at 10 µM through the induction of apoptosis. Read More.
Evaluation of the Antifungal Activity of Natural Xanthones from Garcinia Mangostana and Their Synthetic Derivatives
The antifungal activity of several xanthones isolated from the fruit hulls of Garcinia mangostana and some derivatives of mangostin against three phytopathogenic fungi, Fusarium oxysporum vasinfectum, Alternaria tenuis, and Dreschlera oryzae, has been evaluated. The natural xanthones showed good inhibitory activity against the three fungi. Substitution in the A and C rings has been shown to modify the bioactivities of the compounds. Read More.
Chemical Constituents of Garcinia Mangostana
Garcinia mangostana L. (Guttiferae), the Mangosteen tree, has received rather extensive investigation from various research groups. These investigations have resulted in the isolation of anthocyanin glycosides (1), a benzophenone, maclurin (2), and several xanthone derivatives (3-9), such as mangostin  (8). The usage of the fruit hull (pericarp) in Thai folk medicine (10) for healing skin infection and wounds and for the relief of diarrhea has led us to reexamine the plant with a view to identifying the biologically active compounds. Read More.
Effect of Mangostin, a Xanthone from Garcinia Mangostana Linn. in Immunopathological and Inflammatory Reactions
Mangostin from the rinds of the fruits of G. mangostana inhibited systemic anaphylaxis, Schultz-Dale's reaction and immunocytoadherence in guinea pigs and rats. It also significantly inhibited the primary and secondary responses of adjuvant-induced arthritis in rats. The results have been correlated with previous findings on the pharmacological effects of mangostin and the probable mode of action is discussed. Read More.